Description

(5-Formyl-Pyrimidin-2-Yl)-Methyl-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate and building block. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals, offering a versatile formyl-protected pyrimidine scaffold. It is essential for research and development in medicinal chemistry, particularly for companies developing novel therapeutics in oncology and virology.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside analogs and other small-molecule APIs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a linker or warhead component in the design of targeted protein degraders.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and fungicides.
• Chemical Biology Probes: Utilized in the development of labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of client-specific molecules under cGMP conditions.

Basic Information

Product Name	(5-Formyl-Pyrimidin-2-Yl)-Methyl-Carbamic Acid tert-Butyl Ester
CAS No.	1260876-67-2
Molecular Formula	C12H17N3O3
Molecular Weight	251.28 g/mol
Synonyms	tert-Butyl N-[(5-formylpyrimidin-2-yl)methyl]carbamate; N-[(5-Formyl-2-pyrimidinyl)methyl]carbamic Acid 1,1-Dimethylethyl Ester; BOC-Protected 5-Formyl-2-pyrimidinemethylamine; 2-(((tert-Butoxycarbonyl)amino)methyl)pyrimidine-5-carbaldehyde; (5-Formyl-2-pyrimidinylmethyl)carbamic Acid tert-Butyl Ester; 1260876-67-2; tert-Butyl (5-formylpyrimidin-2-yl)methylcarbamate
EINECS	Contact for details

Quality Control

Every batch of (5-Formyl-Pyrimidin-2-Yl)-Methyl-Carbamic Acid tert-Butyl Ester is manufactured and tested under a rigorous quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting development through to commercial scale. A Certificate of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.