Description

4-(Trifluoromethyl)Pyrimidine-5-Carbonitrile is a high-value fluorinated pyrimidine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique trifluoromethyl and nitrile functional groups make it a versatile building block for constructing complex molecular architectures with enhanced properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science Precursor: Serves as a starting material for the synthesis of specialized ligands, functionalized polymers, and advanced organic electronic materials.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a core scaffold in fragment-based drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	4-(Trifluoromethyl)Pyrimidine-5-Carbonitrile
CAS No.	1260676-79-6
Molecular Formula	C6H2F3N3
Molecular Weight	173.10 g/mol
Synonyms	5-Cyano-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)-5-pyrimidinecarbonitrile; Pyrimidine-5-carbonitrile, 4-(trifluoromethyl)-; 1260676-79-6; 4-Trifluoromethylpyrimidine-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyrimidine-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.