Description

2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Quinolin-4-Yl-Propionic Acid is a specialized Fmoc-protected amino acid derivative, a critical building block in modern peptide synthesis. Its value lies in enabling the precise construction of complex peptides containing the quinoline moiety, which is of significant interest for its biological activity. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of peptides containing quinoline-based unnatural amino acids.
• Pharmaceutical Research & Development: A crucial intermediate in the discovery and development of new therapeutic agents targeting various diseases.
• Combinatorial Chemistry Libraries: Used to generate diverse compound libraries for high-throughput screening in drug discovery programs.
• Bioconjugation: Serves as a linker or functional handle for attaching peptides to other molecules, surfaces, or biomolecules.
• Chemical Biology Probes: Enables the synthesis of labeled peptides for studying protein-protein interactions and cellular processes.
• Academic Research: A valuable reagent for universities and research institutes studying peptide structure, function, and medicinal chemistry.

Basic Information

Product Name	2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Quinolin-4-Yl-Propionic Acid
CAS No.	1260644-17-4
Molecular Formula	C27H20N2O4
Molecular Weight	436.46 g/mol
Synonyms	Fmoc-4-quinolylalanine; Fmoc-Quin(4)-OH; Fmoc-3-(4-Quinolyl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-quinolyl)-L-alanine; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-quinolyl)propanoic acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(quinolin-4-yl)propanoic acid; Fmoc-L-4-quinolylalanine; Fmoc-3-(quinolin-4-yl)-L-alanine
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent Good Manufacturing Practice (GMP) principles where applicable. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.