Description

(2-Cyano-Pyrimidin-5-Yl)-Methyl-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a cyano-pyrimidine core protected by a tert-butyl carbamate group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of targeted therapeutics for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel kinase inhibitors and other small molecule drugs.
• Oncology Drug Discovery: Used in research and development of targeted cancer therapies, leveraging its pyrimidine scaffold.
• Chemical Biology Research: Serves as a versatile precursor for creating molecular probes and tool compounds to study biological pathways.
• Process Chemistry & Scale-up: Employed in the development and optimization of commercial-scale manufacturing routes for APIs.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	(2-Cyano-Pyrimidin-5-Yl)-Methyl-Carbamic Acid tert-Butyl Ester
CAS No.	1260641-26-6
Molecular Formula	C12H14N4O2
Molecular Weight	246.27 g/mol
Synonyms	tert-Butyl N-[(2-cyanopyrimidin-5-yl)methyl]carbamate; 5-[[(tert-Butoxycarbonyl)amino]methyl]pyrimidine-2-carbonitrile; N-Boc-5-(aminomethyl)pyrimidine-2-carbonitrile; Boc-Aminomethyl-pyrimidine-2-carbonitrile; (2-Cyano-5-pyrimidinyl)methylcarbamic acid 1,1-dimethylethyl ester; 5-(Boc-aminomethyl)pyrimidine-2-carbonitrile
EINECS	Contact for details

Quality Control

Our (2-Cyano-Pyrimidin-5-Yl)-Methyl-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring material suitable for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.