Description

n-Fmoc-R-4-Bromophenylglycine CAS NO 1260618-68-5 is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers developing complex peptides and peptidomimetics with enhanced stability and specific biological activity. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and CROs/CDMOs focused on novel therapeutic discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the controlled assembly of custom peptide sequences.
• Pharmaceutical Research: Incorporation into therapeutic peptide candidates to modulate bioactivity, stability, and receptor binding profiles.
• Peptidomimetic Design: Serves as a versatile scaffold for creating non-peptide compounds that mimic peptide function, often with improved pharmacokinetic properties.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• API Intermediate Manufacturing: A critical raw material in the cGMP production of peptide-based Active Pharmaceutical Ingredients (APIs).
• Academic Research: Enables studies in medicinal chemistry, biochemistry, and structural biology requiring precisely modified peptide structures.

Basic Information

Product Name	n-Fmoc-R-4-Bromophenylglycine
CAS No.	1260618-68-5
Molecular Formula	C23H18BrNO4
Molecular Weight	452.30 g/mol
Synonyms	Fmoc-4-Bromo-D-phenylglycine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-bromophenyl)acetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-bromo-D-phenylglycine; Fmoc-D-4-Bromophenylglycine; Fmoc-(R)-4-Bromophenylglycine; N-α-Fmoc-4-bromo-D-phenylglycine; (R)-2-(Fmoc-amino)-2-(4-bromophenyl)acetic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-R-4-Bromophenylglycine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.