Description

(S)-A-(Fmoc-Amino)-[1,1'-Biphenyl]-3-Propanoic Acid CAS NO 1260616-69-0 is a high-purity, non-natural amino acid derivative featuring a biphenyl backbone and an Fmoc-protected amine group. This compound is critically important as a sophisticated building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of rigid, aromatic structural elements. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing novel therapeutics targeting protein-protein interactions and creating constrained peptide libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key, protected amino acid residue for the automated synthesis of peptides containing biphenyl motifs.
• Peptidomimetic Drug Discovery: Used to incorporate rigid, aromatic spacers into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying biological mechanisms and target engagement.
• Pharmaceutical Intermediate: Acts as a critical chiral intermediate in the research-scale synthesis of potential active pharmaceutical ingredients (APIs).
• Combinatorial Chemistry: A valuable component for generating diverse compound libraries focused on peptide-based scaffolds.
• Material Science Research: Can be utilized in the design and synthesis of novel peptide-based polymers or supramolecular structures.

Basic Information

Product Name	(S)-A-(Fmoc-Amino)-[1,1'-Biphenyl]-3-Propanoic Acid
CAS No.	1260616-69-0
Molecular Formula	C30H25NO4
Molecular Weight	463.52 g/mol
Synonyms	(S)-3-(3'-(Fmoc-amino)-[1,1'-biphenyl]-3-yl)propanoic acid; Fmoc-3-(3'-amino-[1,1'-biphenyl]-3-yl)-(S)-propanoic acid; (S)-3-[3'-(9-Fluorenylmethoxycarbonylamino)biphenyl-3-yl]propanoic acid; Fmoc-Abp(3)-OH; Fmoc-3-Amino(1,1'-biphenyl)-3-propionic acid; (S)-α-(Fmoc-Amino)-[1,1'-Biphenyl]-3-propanoic Acid; Biphenyl-based Fmoc-amino acid building block.
EINECS	Contact for details

Quality Control

Our (S)-A-(Fmoc-Amino)-[1,1'-Biphenyl]-3-Propanoic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards for fine chemical production, and custom purity grades or specific impurity profiles can be discussed to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.