Description

Fmoc-2-Methoxy-L-Homophenylalanine is a non-natural, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the research and development of novel peptide-based pharmaceuticals and bioactive compounds. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on peptide drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the automated, stepwise assembly of custom peptide sequences.
• Peptidomimetic Drug Discovery: Incorporation into peptide chains to introduce structural modifications, enhancing metabolic stability, bioavailability, and target binding affinity.
• Research Chemical: Used in academic and industrial laboratories for studying enzyme-substrate interactions, receptor binding, and structure-activity relationships (SAR).
• Synthesis of Constrained Peptides: The homophenylalanine backbone with a methoxy substituent is valuable for creating peptides with specific conformational restraints.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide-like molecules for high-throughput screening against biological targets.
• Intermediate for Bioconjugation: Can be used in the synthesis of peptide-drug conjugates or peptide-labeled probes for diagnostic applications.

Basic Information

Product Name	Fmoc-2-Methoxy-L-Homophenylalanine
CAS No.	1260616-47-4
Molecular Formula	C27H27NO5
Molecular Weight	445.51 g/mol
Synonyms	Fmoc-2-MeO-Hph-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methoxy-L-homophenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-4-(2-methoxyphenyl)butanoic acid; Fmoc-2-Methoxy-L-homoPhe-OH; Fmoc-L-2-Methoxyhomophenylalanine; N-Fmoc-2-methoxy-L-homophenylalanine; 2-Methoxy-L-homophenylalanine, N-Fmoc derivative; Fmoc-2-OMe-Hph-OH
EINECS	Contact for details

Quality Control

Our Fmoc-2-Methoxy-L-Homophenylalanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.