Description

(R)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-(3-Trifluoromethoxy-Phenyl)-Butyric Acid CAS NO 1260616-31-6 is a high-purity, non-natural amino acid derivative featuring a chiral center and a trifluoromethoxy phenyl side chain. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, enabling the development of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for projects targeting neurological disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetic drug candidates.
• Proteomics Research: Used in the design and synthesis of custom peptides for studying protein-protein interactions, enzyme activity, and receptor binding.
• Chemical Biology Tool: Incorporation into peptide libraries for high-throughput screening to identify new lead compounds with enhanced stability and bioavailability.
• API Development: Serves as a crucial intermediate in the research and development of Active Pharmaceutical Ingredients (APIs) with specific stereochemical and pharmacological properties.
• Neurological & Metabolic Research: Particularly valuable for constructing peptides targeting GPCRs and other receptors implicated in CNS and metabolic pathways.

Basic Information

Product Name	(R)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-(3-Trifluoromethoxy-Phenyl)-Butyric Acid
CAS No.	1260616-31-6
Molecular Formula	C26H22F3NO5
Molecular Weight	485.45 g/mol
Synonyms	Fmoc-(R)-3-(3-Trifluoromethoxy-phenyl)-alanine; (R)-Fmoc-3-(3-Trifluoromethoxyphenyl)alanine; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-(trifluoromethoxy)phenyl)butanoic acid; Fmoc-R-3-(3-CF3O-Ph)-Ala-OH; (R)-N-Fmoc-3-(3-trifluoromethoxyphenyl)alanine; Fmoc-(R)-3-(3-Trifluoromethoxyphenyl)alanine; (R)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-trifluoromethoxyphenyl)alanine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of (R)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-(3-Trifluoromethoxy-Phenyl)-Butyric Acid is manufactured under strict quality management systems and is supported by a comprehensive Certificate of Analysis (COA). The COA provides detailed analytical data, including chiral purity, chemical purity (HPLC), and identity confirmation (NMR, MS). Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.