Description

2-Methyl-D-Homophenylalanine is a non-natural, chiral amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the fine-tuning of biological activity and metabolic stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics, particularly in areas requiring high stereochemical purity, such as protease inhibitors and receptor-targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate modified phenylalanine analogs, enhancing peptide stability and selectivity.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various enzymes like renin, HIV protease, and thrombin.
• Chemical Biology Research: Employed as a tool compound to study enzyme-substrate interactions and to develop activity-based probes.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective organic transformations.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2-Methyl-D-Homophenylalanine
CAS No.	1260614-75-2
Molecular Formula	C11H15NO2
Molecular Weight	193.24 g/mol
Synonyms	D-2-Methylhomophenylalanine; (R)-2-Amino-2-methyl-4-phenylbutanoic acid; D-α-Methylhomophenylalanine; Hph(2-Me)-OH (D-form); (2R)-2-Amino-2-methyl-4-phenylbutyric acid; D-2-Methyl-4-phenylbutanoic acid-2-amine; D-2-Methyl-β-homophenylalanine
EINECS	Contact for details

Quality Control

Our 2-Methyl-D-Homophenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.