Description

(R)-2-Amino-4-(4-Trifluoromethylphenyl)Butanoic Acid is a high-purity, non-natural amino acid derivative characterized by its chiral (R)-configuration and a 4-(trifluoromethyl)phenyl side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, offering unique steric and electronic properties due to the trifluoromethyl group. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive molecules where precise stereochemistry is essential for efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in oncology, neurology, and metabolic disease research.
• Peptidomimetics & Constrained Peptides: Used to incorporate non-natural amino acid residues into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric synthesis and catalysis.
• Chemical Biology & Proteomics: Employed in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Agrochemical Research: Potential intermediate in the development of advanced herbicides or pesticides with specific chiral activity.
• Academic & Industrial R&D: Fundamental research tool in synthetic organic chemistry and medicinal chemistry for exploring structure-activity relationships (SAR).

Basic Information

Product Name	(R)-2-Amino-4-(4-Trifluoromethylphenyl)Butanoic Acid
CAS No.	1260614-74-1
Molecular Formula	C11H12F3NO2
Molecular Weight	247.21 g/mol
Synonyms	(R)-2-Amino-4-[4-(trifluoromethyl)phenyl]butanoic acid; (R)-4-(4-Trifluoromethylphenyl)-2-aminobutanoic Acid; D-2-Amino-4-(4-trifluoromethylphenyl)butyric acid; (R)-α-Amino-4-(trifluoromethyl)benzenebutanoic acid; (2R)-2-Amino-4-[4-(trifluoromethyl)phenyl]butanoic acid; (R)-Homo-4-(trifluoromethyl)phenylalanine; (R)-homo-4-CF3-Phe; (R)-4-(4-CF3-Ph)-homoAla
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-4-(4-Trifluoromethylphenyl)Butanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with ICH guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.