Description

(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[2-(Trifluoromethoxy)Phenyl]Butanoic Acid is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical Fmoc-protected building block for the solid-phase synthesis of complex peptides and peptidomimetics. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors to create novel therapeutic candidates targeting a range of diseases.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Medicinal Chemistry & Drug Discovery: Used to incorporate the unique 2-(trifluoromethoxy)phenyl side chain into peptide backbones, enabling structure-activity relationship (SAR) studies and the optimization of drug candidates for improved potency, selectivity, and metabolic stability.
• Peptidomimetic Development: Essential for synthesizing modified peptides that mimic natural protein structures but with enhanced pharmacological properties, such as increased oral bioavailability.
• API Intermediate Synthesis: Acts as a key chiral intermediate in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Bioconjugation & Probe Design: Useful for creating labeled peptides or peptide-based probes for diagnostic imaging, target identification, and biochemical assays.

Basic Information

Product Name	(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[2-(Trifluoromethoxy)Phenyl]Butanoic Acid
CAS No.	1260611-80-0
Molecular Formula	C26H22F3NO5
Molecular Weight	485.45 g/mol
Synonyms	Fmoc-2-(2-Trifluoromethoxyphenyl)alanine; Fmoc-2-(2-Tfm-Phe)-OH; Fmoc-(2-Tfm)Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(2-(trifluoromethoxy)phenyl)-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-[2-(trifluoromethoxy)phenyl]butanoic acid; Fmoc-L-2-(2-OCH3CF3)Phe-OH; Fmoc-2-(2-CF3O-Phg)-OH
EINECS	Contact for details

Quality Control

Every batch of this advanced pharmaceutical intermediate is produced under strict quality management systems. We employ rigorous analytical techniques, including HPLC, NMR, and MS, to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.