Description

Fmoc-3-Methoxy-L-Homophenylalanine is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the research and development of novel peptide-based pharmaceuticals and biochemical tools. It is primarily utilized by research institutions, pharmaceutical R&D departments, and CROs specializing in peptide chemistry to introduce a modified phenylalanine residue with enhanced lipophilicity and steric properties into peptide chains.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of custom peptides.
• Pharmaceutical Research: Used to incorporate modified amino acids into peptide drug candidates to improve metabolic stability, receptor binding affinity, or membrane permeability.
• Peptidomimetic Development: Serves as a key intermediate in creating peptide analogs and mimetics for drug discovery programs targeting GPCRs, enzymes, and other biological targets.
• Bioconjugation: The reactive carboxyl and amine (when deprotected) groups enable its use in linking peptides to other molecules, surfaces, or reporter tags.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides used as probes to study protein-protein interactions and cellular processes.
• Academic Research: Essential for university and institutional labs investigating peptide structure-activity relationships (SAR) and novel synthetic methodologies.

Basic Information

Product Name	Fmoc-3-Methoxy-L-Homophenylalanine
CAS No.	1260610-23-8
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-3-methoxy-L-homophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-L-homophenylalanine; Fmoc-Hph(3-OMe)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(3-methoxyphenyl)butanoic acid; N-α-Fmoc-3-methoxy-L-homophenylalanine; Fmoc-L-3-methoxyhomophenylalanine; Fmoc-3-MeO-Hph-OH
EINECS	Contact for details

Quality Control

Our Fmoc-3-Methoxy-L-Homophenylalanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.