Description

Fmoc-3,4-Difluoro-D-Homophenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing a rigid, fluorinated aromatic side chain with specific stereochemistry into peptide sequences, which can significantly influence their biological activity, stability, and binding affinity. It is an essential building block for pharmaceutical researchers and peptide manufacturers developing novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tert-butyl strategy, enabling the controlled assembly of complex peptides.
• Pharmaceutical Research & Development: Used to synthesize peptide-based drug candidates, particularly for targeting protein-protein interactions where fluorination enhances metabolic stability and lipophilicity.
• Peptidomimetics Design: Incorporation into peptide backbones to create analogs with improved pharmacological profiles, such as increased bioavailability and receptor selectivity.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying enzyme mechanisms, cellular pathways, and biomarker discovery.
• Agrochemical Research: Potential use in developing novel bioactive peptides for crop protection.
• Material Science: Building block for constructing functionalized polymers and advanced biomaterials with specific surface properties.

Basic Information

Product Name	Fmoc-3,4-Difluoro-D-Homophenylalanine
CAS No.	1260609-50-4
Molecular Formula	C25H21F2NO4
Molecular Weight	437.44 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-difluoro-D-homophenylalanine; Fmoc-3,4-Difluoro-D-homoPhe-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-4-(3,4-difluorophenyl)butanoic acid; Fmoc-D-3,4-Difluorohomophenylalanine; N-Fmoc-3,4-difluoro-D-homophenylalanine; Fmoc-D-homoPhe(3,4-F2)-OH; Fmoc-3,4-Difluoro-D-hPhe
EINECS	Contact for details

Quality Control

Our Fmoc-3,4-Difluoro-D-Homophenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and production. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.