Description

Fmoc-2,3-Difluoro-L-Homophenylalanine is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound matters as a critical building block for introducing a difluorinated homophenylalanine moiety, which can significantly enhance the metabolic stability, bioavailability, and binding affinity of therapeutic peptides. Pharmaceutical researchers and peptide manufacturers need it for the development of novel peptide-based drugs, proteomics research, and the creation of specialized biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptidomimetic Design: Used to incorporate fluorine atoms into peptide backbones, improving resistance to enzymatic degradation and enhancing membrane permeability.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling of peptides with fluorophores or other tags for diagnostic and research applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Industrial R&D: Essential for basic research in medicinal chemistry, chemical biology, and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Fmoc-2,3-Difluoro-L-Homophenylalanine
CAS No.	1260609-44-6
Molecular Formula	C25H21F2NO4
Molecular Weight	437.44 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3-difluoro-L-homophenylalanine; Fmoc-2,3-Difluoro-L-homoPhe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-4-(2,3-difluorophenyl)butanoic acid; N-Fmoc-2,3-difluoro-L-homophenylalanine; Fmoc-L-2,3-Difluorohomophenylalanine; N-α-Fmoc-2,3-difluoro-L-homophenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-2,3-Difluoro-L-Homophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the exacting standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.