Description

n-Fmoc-S-3-Chlorophenylglycine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block enables the precise incorporation of the S-3-chlorophenylglycine moiety into complex peptide sequences, a critical step in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to introduce structural diversity and specific pharmacophores into peptide backbones to enhance stability, bioavailability, and target affinity.
• Bioconjugation: Can be employed in the synthesis of peptide conjugates for diagnostic and therapeutic applications.
• Chemical Biology Research: A valuable tool for probing protein-protein interactions and enzyme mechanisms through the incorporation of non-natural amino acids.
• Process Development: Used in scaling up the production of peptide sequences containing chlorinated aromatic side chains for clinical and commercial supply.

Basic Information

Product Name	n-Fmoc-S-3-Chlorophenylglycine
CAS No.	1260608-79-4
Molecular Formula	C23H18ClNO4
Molecular Weight	407.85 g/mol
Synonyms	Fmoc-3-Cl-Phg-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3-chlorophenyl)acetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-chloro-L-phenylglycine; Fmoc-L-3-chlorophenylglycine; N-α-Fmoc-S-3-chlorophenylglycine; Fmoc-3-chloro-L-homophenylglycine; Fmoc-(S)-3-chlorophenylglycine
EINECS	Contact for details

Quality Control

Our n-Fmoc-S-3-Chlorophenylglycine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.