Description

(S)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-p-Tolyl-Acetic Acid CAS NO 1260607-12-2 is a high-purity, non-natural amino acid derivative featuring a chiral center and an Fmoc-protected amino group. This compound is a critical building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry and molecular architecture. It is primarily utilized by pharmaceutical R&D and biotechnology organizations engaged in drug discovery, particularly for developing novel therapeutic agents targeting protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral amino acid component for the automated synthesis of custom peptides with specific (S)-configuration.
• Pharmaceutical Intermediates: Serves as a crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Research: Used to create modified peptide analogs with enhanced stability, bioavailability, or receptor selectivity for medicinal chemistry programs.
• Bioconjugation: Employed in the design and synthesis of peptide-based linkers for antibody-drug conjugates (ADCs) and other targeted therapies.
• Chemical Biology Probes: Integral for constructing labeled or tagged peptides used in biochemical assays and proteomics research.
• Academic & Institutional Research: Supports fundamental studies in organic chemistry, peptide science, and structural biology.

Basic Information

Product Name	(S)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-p-Tolyl-Acetic Acid
CAS No.	1260607-12-2
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	(S)-Fmoc-4-methylphenylglycine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-methylphenyl)acetic acid; Fmoc-(S)-4-MePhg-OH; Fmoc-(S)-4-methylphenylglycine; (S)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methylphenylglycine; (S)-2-(Fmoc-amino)-2-(p-tolyl)acetic acid; (S)-N-Fmoc-4-methylphenylglycine; Fmoc-4-Me-Phg-OH (S-isomer)
EINECS	Contact for details

Quality Control

Our (S)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-p-Tolyl-Acetic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral purity verification. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment. Production can adhere to cGMP guidelines for advanced pharmaceutical development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.