Description

(R)-(3-Bromo-Phenyl)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a bromo-phenyl side chain, protected by the Fmoc (9-fluorenylmethoxycarbonyl) group. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise introduction of a brominated aromatic moiety for further functionalization. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutic peptides, protein engineering, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid derivative for the automated synthesis of custom peptides containing bromo-phenylalanine analogs.
• Pharmaceutical Research: A key intermediate in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Chemical Biology: Used to incorporate a site-specific handle (bromine atom) into peptides for subsequent bioconjugation via cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Peptidomimetic Design: Serves as a scaffold for creating modified peptides with enhanced stability, bioavailability, or receptor binding affinity.
• Academic & Contract Research: Essential reagent for research into peptide structure-activity relationships (SAR) and novel synthetic methodologies.
• Libraries for Screening: Used in the generation of diverse peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	(R)-(3-Bromo-Phenyl)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid
CAS No.	1260605-67-1
Molecular Formula	C23H18BrNO4
Molecular Weight	452.30 g/mol
Synonyms	Fmoc-3-Bromo-D-phenylglycine; Fmoc-3-Br-D-Phg-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(3-bromophenyl)acetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-bromo-D-phenylglycine; Fmoc-D-3-Bromophenylglycine; N-Fmoc-3-bromo-D-phenylglycine; Fmoc-3-Bromo-D-α-phenylglycine
EINECS	Contact for details

Quality Control

Our (R)-(3-Bromo-Phenyl)-[(9H-Fluoren-9-Ylmethoxycarbonylamino)]-Acetic Acid is manufactured under strict quality control protocols to ensure the high purity and chiral integrity required for sensitive peptide synthesis. Each batch is tested to meet exacting standards, with comprehensive analytical data provided. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.