Description

n-Fmoc-2,3-Difluoro-L-Phenylalanine is a high-purity, fluorinated amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of difluorinated phenylalanine residues into complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostic agents, and biochemical tools where the introduction of fluorine atoms can significantly alter a molecule's metabolic stability, lipophilicity, and binding affinity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of fluorinated peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide drugs where fluorination is used to optimize pharmacokinetic properties.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorinated peptide probes for imaging and diagnostic applications.
• Chemical Biology Studies: Employed to investigate the role of specific fluorinated amino acids in protein structure, function, and stability.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specialized fluorinated peptide sequences.
• Material Science: Potential use in the synthesis of advanced biomaterials and peptidomimetics with tailored surface properties.

Basic Information

Product Name	n-Fmoc-2,3-Difluoro-L-Phenylalanine
CAS No.	1260605-30-8
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-2,3-Difluoro-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(2,3-difluorophenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3-difluoro-L-phenylalanine; N-Fmoc-2,3-difluoro-L-phenylalanine; Fmoc-DifluoroPhe-OH; Fmoc-2,3-F2-Phe-OH; Fmoc-L-2,3-Difluorophenylalanine
EINECS	Contact for details

Quality Control

Our n-Fmoc-2,3-Difluoro-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates. Specifications are designed to meet the stringent requirements of advanced peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.