Description

(S)-3-Cyclopropyl-3-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a cyclopropyl side chain and an Fmoc-protected amine group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of conformational constraints to enhance biological activity and metabolic stability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents, including protease inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for constrained peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as an Fmoc-protected amino acid to incorporate the cyclopropylglycine moiety.
• Peptidomimetic Design: Essential for creating peptidomimetics where the cyclopropyl group restricts backbone flexibility, improving target selectivity and oral bioavailability.
• Protease Inhibitor Development: Serves as a core structure in the design of inhibitors for various proteases (e.g., HCV NS3/4A, HIV protease).
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by incorporating non-standard amino acids into peptides.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for clinical trials.

Basic Information

Product Name	(S)-3-Cyclopropyl-3-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid
CAS No.	1260605-12-6
Molecular Formula	C21H21NO4
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-Cpg-OH; Fmoc-(S)-Cyclopropylglycine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-2-cyclopropylacetic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-cyclopropylglycine; Fmoc-L-Cyclopropylglycine; Fmoc-Cpr-OH; Nα-Fmoc-L-cyclopropylglycine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-cyclopropylacetic Acid
EINECS	Contact for details

Quality Control

Our (S)-3-Cyclopropyl-3-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.