Description

(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[4-(Trifluoromethoxy)Phenyl]Butanoic Acid is a high-purity, non-natural amino acid derivative featuring a trifluoromethoxy phenyl side chain and Fmoc-protected amine. This compound is a critical building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural and electronic properties. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in drug discovery and development programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid for the automated synthesis of custom peptides.
• Peptidomimetic Drug Discovery: Incorporation into peptide backbones to enhance metabolic stability, membrane permeability, and binding affinity.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• API Intermediate Development: Serving as a key chiral intermediate in the research-scale synthesis of potential therapeutic candidates.
• Library Synthesis: For creating focused chemical libraries of peptide-like compounds for high-throughput screening.

Basic Information

Product Name	(2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-[4-(Trifluoromethoxy)Phenyl]Butanoic Acid
CAS No.	1260604-66-7
Molecular Formula	C26H22F3NO5
Molecular Weight	485.45 g/mol
Synonyms	Fmoc-4-(4-(Trifluoromethoxy)phenyl)-L-homoalanine; Fmoc-Hph(4-CF3O)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[4-(trifluoromethoxy)phenyl]-L-homoalanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-[4-(trifluoromethoxy)phenyl]butanoic acid; Fmoc-L-4-(4-(Trifluoromethoxyphenyl))homoalanine; Fmoc-4-(4-CF3O-Ph)-L-HAla-OH; Nα-Fmoc-4-(4-trifluoromethoxyphenyl)-L-homoalanine
EINECS	Contact for details

Quality Control

Our production of this Fmoc-protected amino acid adheres to stringent GMP-like guidelines to ensure batch-to-batch consistency for research and development. Every lot is subjected to comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.