Description

(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-(Pyridin-4-Yl)Butanoic Acid CAS NO 1260604-16-7 is a sophisticated, optically pure Fmoc-protected amino acid derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex peptides and peptidomimetics, particularly those requiring the incorporation of a pyridyl side chain for enhanced binding or catalytic activity. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science who demand reliable, high-quality raw materials for their most sensitive synthetic workflows.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of peptides containing 4-pyridylalanine residues.
• Pharmaceutical Intermediates: Used in the research and development of novel drug candidates, especially in oncology and neurology targeting protein-protein interactions.
• Peptidomimetic Design: Facilitates the creation of non-natural peptide analogs with improved metabolic stability and bioavailability.
• Bioconjugation and Labeling: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for studying enzyme mechanisms and biological pathways.
• Catalyst and Ligand Development: The pyridyl moiety makes it a valuable scaffold for constructing chiral ligands and organocatalysts.

Basic Information

Item	Details
Product Name	(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-4-(Pyridin-4-Yl)Butanoic Acid
CAS No.	1260604-16-7
Molecular Formula	C24H20N2O4
Molecular Weight	400.43 g/mol
Synonyms	Fmoc-(R)-4-Pyridylalanine; Fmoc-D-4-Pal-OH; Fmoc-(R)-2-Amino-4-(4-pyridyl)butyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-pyridyl-D-homoalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(pyridin-4-yl)butanoic acid; Fmoc-4-Pal(4)-OH; Fmoc-D-4-Pyridyl-Ala-OH; Boc-D-4-Pal-OH (common related variant)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment, supporting compliance in GMP-related research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.