Description

Fmoc-2,6-Difluoro-D-Homophenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is critical for introducing the unique steric and electronic properties of a difluorinated aromatic side chain into peptide backbones, which can significantly enhance metabolic stability and binding affinity. It is an essential building block for medicinal chemists and researchers in the pharmaceutical and biotechnology industries developing novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled incorporation of a difluorinated D-homophenylalanine residue.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of peptide drugs targeting GPCRs, enzymes, and protein-protein interactions.
• Peptidomimetic Design: Used to create analogs with improved pharmacological profiles, such as enhanced bioavailability, proteolytic resistance, and target selectivity.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying biological mechanisms and pathways.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to discover new bioactive compounds.
• API Development: Supports the process development and scale-up of active pharmaceutical ingredients (APIs) containing non-standard amino acids.

Basic Information

Product Name	Fmoc-2,6-Difluoro-D-Homophenylalanine
CAS No.	1260601-15-7
Molecular Formula	C25H21F2NO4
Molecular Weight	437.44 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,6-difluoro-D-homophenylalanine; Fmoc-2,6-Difluoro-D-homoPhe-OH; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(2,6-difluorophenyl)butanoic acid; N-Fmoc-2,6-difluoro-D-homophenylalanine; Fmoc-D-2,6-Difluoro-homoPhe; Fmoc-(2,6-F2)-D-hPhe-OH; 9-Fluorenylmethyloxycarbonyl-2,6-difluoro-D-homophenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-2,6-Difluoro-D-Homophenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.