Description

(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-(4-Methoxyphenyl)Propanoic Acid is a high-purity, non-natural amino acid derivative protected with the Fmoc (9-fluorenylmethoxycarbonyl) group. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the controlled introduction of a methylated, methoxyphenylalanine side chain. It is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing therapeutic peptides, protease inhibitors, and bioactive probes. The chiral purity and defined structure are paramount for ensuring the biological activity and consistency of the final peptide products.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise assembly of custom peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Incorporates a non-proteinogenic side chain to enhance metabolic stability, bioavailability, and target binding affinity of peptide leads.
• Bioconjugation & Probe Development: Serves as a specialized component for creating labeled peptides, affinity tags, or diagnostic agents.
• Academic & Institutional Research: A vital reagent for studying protein-protein interactions, signal transduction pathways, and structure-activity relationships (SAR).
• Contract Manufacturing (CMO/CDMO): A specified raw material for the GMP-compliant production of clinical and commercial peptide APIs.

Basic Information

Product Name	(S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-(4-Methoxyphenyl)Propanoic Acid
CAS No.	1260595-45-6
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-N-Me-4-methoxy-L-phenylalanine; Fmoc-N-Methyl-4-methoxy-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-4-methoxy-L-phenylalanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-(4-methoxyphenyl)propanoic acid; Fmoc-N-Me-(4-OMe)-Phe-OH; Nα-Fmoc-Nα-methyl-4-methoxy-L-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of our (S)-2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)(Methyl)Amino)-3-(4-Methoxyphenyl)Propanoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for peptide synthesis, including HPLC purity (typically ≥98%), confirmation of chiral integrity, and specified limits for residual solvents. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.