Description

n-Fmoc-(S)-3-Fluorohomophenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This fluorinated building block is critical for introducing specific conformational and electronic properties into peptide chains, enhancing metabolic stability and binding affinity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and PROTACs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex fluorinated peptides.
• Pharmaceutical Intermediates: Serves as a crucial building block in the research and development of active pharmaceutical ingredients (APIs) targeting various diseases.
• Peptidomimetic Design: Used to create stable peptide analogs with improved pharmacokinetic properties by incorporating a fluorine atom at the homophenylalanine side chain.
• Chemical Biology Probes: Enables the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• PROTAC (Proteolysis Targeting Chimera) Development: A valuable component in constructing the peptide-based linker regions of bifunctional molecules.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry for structure-activity relationship (SAR) studies.

Basic Information

Product Name	n-Fmoc-(S)-3-Fluorohomophenylalanine
CAS No.	1260594-44-2
Molecular Formula	C25H22FNO4
Molecular Weight	419.45 g/mol
Synonyms	Fmoc-3-F-homoPhe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-fluoro-L-homophenylalanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-fluorophenyl)butanoic acid; Fmoc-L-3-fluorohomophenylalanine; N-Fmoc-3-fluoro-L-homophenylalanine; 3-Fluoro-L-homophenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-3-Fluoro-hPhe-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-(S)-3-Fluorohomophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.