Description

n-Fmoc-2-(Trifluoromethoxy)-L-Phenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for introducing the unique 2-(trifluoromethoxy)phenylalanine moiety into peptide chains, which can significantly alter the biological activity, metabolic stability, and lipophilicity of the target molecule. It is essential for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on developing novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy synthesis of complex peptides containing fluorinated aromatic side chains.
• Medicinal Chemistry & Drug Discovery: Used to incorporate the trifluoromethoxy group into peptide backbones to enhance binding affinity, improve membrane permeability, and increase metabolic resistance.
• Chemical Biology Probes: Serves as a precursor for synthesizing labeled or modified peptides used in studying protein-protein interactions and enzyme mechanisms.
• Pharmaceutical Intermediate: A crucial raw material in the multi-step synthesis of active pharmaceutical ingredients (APIs) for potential therapeutic agents.
• Peptidomimetic Development: Enables the creation of peptide mimics with tailored properties for enhanced efficacy and stability in biological systems.

Basic Information

Product Name	n-Fmoc-2-(Trifluoromethoxy)-L-Phenylalanine
CAS No.	1260593-24-5
Molecular Formula	C25H20F3NO5
Molecular Weight	471.42 g/mol
Synonyms	Fmoc-2-(Trifluoromethoxy)-L-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-(trifluoromethoxy)-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-[2-(trifluoromethoxy)phenyl]propanoic acid; Fmoc-Tfm(2)-L-Phe-OH; Fmoc-L-Phe(2-OCF3)-OH; N-α-Fmoc-O2-(trifluoromethyl)-L-tyrosine derivative; Protected 2-(Trifluoromethoxy)phenylalanine
EINECS	Contact for details

Quality Control

Our n-Fmoc-2-(Trifluoromethoxy)-L-Phenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural confirmation. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.