Description

Fmoc-3-Trifluoromethyl-L-Homophenylalanine is a non-natural, fluorinated amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is engineered to introduce the unique physicochemical properties of the trifluoromethyl group—such as enhanced lipophilicity, metabolic stability, and electron-withdrawing effects—into peptide sequences. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, particularly for developing novel therapeutic peptides, peptidomimetics, and bioconjugates where precise structural modification is critical for activity and stability.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of fluorinated peptide-based drug candidates targeting GPCRs, enzymes, and other biological targets.
• Peptidomimetic Design: Used to create stable peptide analogs with improved bioavailability and resistance to enzymatic degradation by incorporating the trifluoromethyl group.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Material Science & Specialty Polymers: Serves as a monomer for constructing fluorinated polyamides or peptide-inspired polymers with specific surface properties.
• Agrochemical Innovation: Potential use in developing novel, bioactive peptide derivatives for crop protection agents.

Basic Information

Product Name	Fmoc-3-Trifluoromethyl-L-Homophenylalanine
CAS No.	1260593-06-3
Molecular Formula	C₂₆H₂₂F₃NO₄
Molecular Weight	469.45 g/mol
Synonyms	Fmoc-3-(Trifluoromethyl)-L-homophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethyl)-L-homophenylalanine; Fmoc-L-3-CF3-homoPhe-OH; Fmoc-3-CF3-hPhe(4)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-4-[3-(trifluoromethyl)phenyl]butanoic acid; Fmoc-3-Trifluoromethyl-L-hPhe; Fmoc-Tfm-L-hPhe
EINECS	Contact for details

Quality Control

Our Fmoc-3-Trifluoromethyl-L-Homophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.