Description

n-Fmoc-3-(Trifluoromethoxy)-L-Phenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound matters as a critical building block for introducing the unique 3-(trifluoromethoxy)phenyl moiety into peptide chains, a modification that can significantly enhance metabolic stability, lipophilicity, and binding affinity in drug candidates. It is primarily needed by medicinal chemists and process development scientists in pharmaceutical R&D, biotechnology, and fine chemical synthesis for creating novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy synthesis of complex peptides containing the 3-(trifluoromethoxy)phenylalanine residue.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide-based drug candidates, where the trifluoromethoxy group is leveraged to fine-tune ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) properties.
• Peptidomimetic Development: Serves as a precursor for creating non-peptide analogs that mimic the structure and function of bioactive peptides.
• Chemical Biology Probes: Incorporated into peptides used as tools to study protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• API Intermediate Synthesis: An important intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for clinical trials and commercial manufacturing.
• High-Value Fine Chemical Production: Employed in custom synthesis and contract manufacturing of specialized, high-potency compounds.

Basic Information

Product Name	n-Fmoc-3-(Trifluoromethoxy)-L-Phenylalanine
CAS No.	1260592-32-2
Molecular Formula	C25H20F3NO5
Molecular Weight	471.42 g/mol
Synonyms	Fmoc-3-(Trifluoromethoxy)-L-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(trifluoromethoxy)-L-phenylalanine; Fmoc-Tfm-L-Phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-[3-(trifluoromethoxy)phenyl]propanoic acid; Fmoc-3-(CF3O)-Phe-OH; N-α-Fmoc-3-(Trifluoromethoxy)-L-phenylalanine; Fmoc-L-Phe(3-OCF3)-OH; Fmoc-3-(Trifluoromethoxy)phenylalanine
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-(Trifluoromethoxy)-L-Phenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.