Description

Fmoc-4-Trifluoromethyl-L-Homophenylalanine CAS NO 1260591-49-8 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing the unique physicochemical properties of the trifluoromethyl group into peptide sequences, enhancing metabolic stability and lipophilicity. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, particularly in the development of novel therapeutics and bioactive peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptides.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs) and drug candidates targeting various diseases.
• Peptidomimetic Design: Incorporates the trifluoromethyl group to mimic natural peptides while improving drug-like properties such as bioavailability and binding affinity.
• Bioconjugation and Probe Development: Serves as a precursor for creating labeled peptides or probes used in biochemical and diagnostic assays.
• Chemical Biology Research: A valuable tool for studying protein-protein interactions and enzyme mechanisms by incorporating fluorinated analogs.
• Material Science: Potential use in the synthesis of specialized polymers and advanced materials with tailored surface properties.

Basic Information

Item	Details
Product Name	Fmoc-4-Trifluoromethyl-L-Homophenylalanine
CAS No.	1260591-49-8
Molecular Formula	C26H22F3NO4
Molecular Weight	469.45 g/mol
Synonyms	Fmoc-4-(Trifluoromethyl)-L-homophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(trifluoromethyl)-L-homophenylalanine; Fmoc-4-CF3-L-homophe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-[4-(trifluoromethyl)phenyl]butanoic acid; Fmoc-L-4-CF3-homoPhe; N-α-Fmoc-4-trifluoromethyl-L-homophenylalanine; Fmoc-4-Trifluoromethyl-L-homophe
EINECS	Contact for details

Quality Control

Our Fmoc-4-Trifluoromethyl-L-Homophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.