Description

(S)-A-(Fmoc-Amino)-3,5-Difluorobenzenebutanoic Acid CAS NO 1260591-27-2 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a 3,5-difluorophenyl side chain. This compound is essential for the solid-phase peptide synthesis (SPPS) of complex peptides requiring fluorinated aromatic residues, which can significantly alter biological activity and stability. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a specialized, fluorinated amino acid building block for automated peptide synthesizers.
• Pharmaceutical Research & Development: Incorporation into peptide drug candidates to enhance metabolic stability, binding affinity, and membrane permeability.
• Peptidomimetic Design: Serves as a key intermediate for creating modified peptide structures that mimic natural peptides.
• Chemical Biology & Proteomics: Used in the synthesis of labeled peptides for studying protein-protein interactions and enzyme mechanisms.
• Antibody-Drug Conjugate (ADC) Linker/Payload Construction: Potential use in the synthesis of peptide-based linkers or cytotoxic peptide payloads.
• Material Science: Exploration in creating specialized fluorinated biomaterials or surface coatings.

Basic Information

Product Name	(S)-A-(Fmoc-Amino)-3,5-Difluorobenzenebutanoic Acid
CAS No.	1260591-27-2
Molecular Formula	C25H21F2NO4
Molecular Weight	437.44 g/mol
Synonyms	(S)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,5-difluorophenyl)butanoic acid; Fmoc-3-(3,5-Difluorophenyl)-L-homoalanine-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3,5-difluorophenyl)butanoic acid; Fmoc-L-3,5-Difluorophe-OH; Fmoc-3,5-Difluoro-L-phenylalanine derivative; (S)-N-Fmoc-3,5-difluorohomophenylalanine; (S)-A-(Fmoc-Amino)-3,5-Difluorobenzenebutanoic Acid CAS NO 1260591-27-2
EINECS	Contact for details

Quality Control

Our (S)-A-(Fmoc-Amino)-3,5-Difluorobenzenebutanoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with pharmaceutical research standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use (up to one month), storage at 2-8°C in a desiccator is acceptable.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.