Description

(S)-4-(3-Bromo-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Butyric Acid is a sophisticated, non-natural amino acid derivative protected with the Fmoc (9-fluorenylmethoxycarbonyl) group. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing targeted therapeutics and diagnostic agents. The bromophenyl moiety provides a versatile handle for further functionalization via cross-coupling reactions, making it a valuable intermediate in medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental monomer for the automated synthesis of custom peptides containing brominated phenylalanine analogs.
• Medicinal Chemistry & Drug Discovery: Serves as a key chiral intermediate for constructing peptide-based drug candidates, enzyme inhibitors, and receptor ligands.
• Chemical Biology Research: Used to incorporate a stable, functionalizable bromine tag into peptides for bioconjugation, protein labeling, or structure-activity relationship (SAR) studies.
• Pharmaceutical Intermediate: A precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting neurological disorders, oncology, and metabolic diseases.
• Peptidomimetic Development: Essential for creating modified peptides with enhanced stability, bioavailability, and target specificity.
• Academic & Industrial R&D: Employed in research laboratories for exploring novel synthetic methodologies and developing new bioactive compounds.

Basic Information

Item	Details
Product Name	(S)-4-(3-Bromo-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Butyric Acid
CAS No.	1260590-73-5
Molecular Formula	C25H22BrNO4
Molecular Weight	480.35 g/mol
Synonyms	Fmoc-3-Br-Phe-OH; Fmoc-3-Bromophenylalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-bromophenyl)propanoic acid; N-α-Fmoc-3-bromo-L-phenylalanine; Fmoc-L-3-bromophenylalanine; Fmoc-3-Br-L-Phe-OH; 3-Bromo-L-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-3-Bromo-L-Phenylalanine
EINECS	Contact for details

Quality Control

Our production of (S)-4-(3-Bromo-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Butyric Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and pharmaceutical applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We operate under a quality management system and can support development projects requiring compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.