Description

8-Hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one is a high-value, heterocyclic organic compound featuring a trifluoromethyl group, a key structural motif prized in modern chemical synthesis. This compound matters as a sophisticated building block or intermediate for research and development in advanced material and life sciences. It is primarily needed by pharmaceutical R&D teams and specialty chemical manufacturers focused on creating novel active ingredients, agrochemicals, and functional materials where the introduction of fluorine atoms is critical for modulating biological activity, stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, or infectious diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, or insecticides, where the trifluoromethyl group can enhance lipophilicity and biological activity.
• Material Science: Acts as a building block for advanced organic materials, such as organic light-emitting diodes (OLEDs) or liquid crystals, where its heterocyclic core contributes to electronic properties.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms or protein-ligand interactions in biochemical research.
• Fluorine Chemistry: A valuable substrate for further fluorination or functionalization reactions, enabling the exploration of structure-activity relationships (SAR) in discovery chemistry.

Basic Information

Product Name	8-Hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
CAS No.	1260585-14-5
Molecular Formula	C9H8F3N3O2
Molecular Weight	247.18 g/mol
Synonyms	8-Hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6-one; 1H-Pyrimido[1,2-a]pyrimidin-6(2H)-one, 8-hydroxy-2-(trifluoromethyl)-3,4-dihydro-; 1260585-14-5; 2-(Trifluoromethyl)-8-hydroxy-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one; 8-Hydroxy-2-trifluoromethyl-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
EINECS	Contact for details

Quality Control

Our 8-Hydroxy-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing key specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports research and development applications requiring reliable and well-characterized advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.