Description

(S)-8-Chloro-2-(Trifluoromethyl)-3,4-Dihydro-1H-Pyrimido[1,2-A]Pyrimidin-6(2H)-One is a high-value, chiral pharmaceutical intermediate characterized by its unique fused pyrimidine core and trifluoromethyl group. This compound is critical for medicinal chemistry research and development, offering a sophisticated building block for creating novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and binding affinity. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of targeted therapeutics, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• API Development: Integral in the development and scale-up processes for new active pharmaceutical ingredients, especially those requiring a (S)-configured stereocenter.
• Preclinical Studies: Employed in the preparation of compounds for pharmacological evaluation, toxicology assessments, and metabolic studies.
• Chemical Biology Probes: Utilized to create specialized molecular tools for investigating enzyme function and cellular signaling mechanisms.
• Asymmetric Synthesis: Acts as a sophisticated substrate or intermediate in catalytic asymmetric transformations to create complex molecular architectures.

Basic Information

Product Name	(S)-8-Chloro-2-(Trifluoromethyl)-3,4-Dihydro-1H-Pyrimido[1,2-A]Pyrimidin-6(2H)-One
CAS No.	1260585-11-2
Molecular Formula	C9H7ClF3N3O
Molecular Weight	265.62 g/mol
Synonyms	(S)-8-Chloro-2-(trifluoromethyl)-2,3,4,6-tetrahydro-1H-pyrimido[1,2-a]pyrimidin-6-one; (6S)-8-Chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6-one; UNII-1W8I7188Y1; 1W8I7188Y1; SCHEMBL21806227; AKOS025147319; ZINC000257425509; (S)-enantiomer of 8-chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
EINECS	Contact for details

Quality Control

Our production of (S)-8-Chloro-2-(Trifluoromethyl)-3,4-Dihydro-1H-Pyrimido[1,2-A]Pyrimidin-6(2H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical characterization, including chiral purity verification, to meet the exacting standards of pharmaceutical development. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and enantiomeric excess are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.