Description

4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine-4-Acetic Acid, 6-(4-Chlorophenyl)-8-Methoxy-1-Methyl- is a high-purity, advanced pharmaceutical intermediate belonging to the triazolobenzodiazepine class. This compound is critical for the research and development of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel triazolobenzodiazepine-based active pharmaceutical ingredients (APIs).
• Neurological Research: Used in preclinical research for developing potential anxiolytic, sedative, or anticonvulsant drug candidates.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for studying benzodiazepine receptor pharmacology and drug metabolism.

Basic Information

Product Name	4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine-4-Acetic Acid, 6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-
CAS No.	1260530-42-4
Molecular Formula	C20H17ClN4O3
Molecular Weight	396.83 g/mol
Synonyms	6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid; 1-Methyl-6-(4-chlorophenyl)-8-methoxy-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid; Triazolobenzodiazepine acetic acid derivative; CAS 1260530-42-4
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and manufacturing applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.