Description

4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine-4-Acetic Acid, 6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-, Methyl Ester is a high-purity, complex heterocyclic compound that serves as a critical advanced intermediate in modern pharmaceutical research and development. Its intricate fused-ring structure makes it a valuable building block for synthesizing novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of new drug candidates.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of new benzodiazepine and triazolobenzodiazepine analog-based drugs.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize pharmacological properties.
• API Synthesis: Integral building block in the multi-step synthesis of potential active pharmaceutical ingredients targeting the central nervous system (CNS).
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the life sciences sector.

Basic Information

Product Name	4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine-4-Acetic Acid, 6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-, Methyl Ester
CAS No.	1260530-41-3
Molecular Formula	C21H19ClN4O3
Molecular Weight	410.85 g/mol
Synonyms	Methyl 6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetate; 6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester; Triazolobenzodiazepine derivative CAS 1260530-41-3; 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid, 6-(4-chlorophenyl)-8-methoxy-1-methyl-, methyl ester
EINECS	Contact for details

Quality Control

Our 4H-[1,2,4]Triazolo[4,3-A][1,4]Benzodiazepine-4-Acetic Acid, 6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.