Description

tert-Butyl 3-(6-Hydroxy-2-Methylpyrimidin-4-Yl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core substituted with a hydroxypyrimidine moiety. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Used in the pilot-scale and commercial-scale production of active pharmaceutical ingredients (APIs) requiring its specific heterocyclic structure.
• Chemical Synthesis: Employed in organic synthesis for the introduction of the protected piperidine-pyrimidine unit into more complex molecular architectures.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial drug substances.

Basic Information

Product Name	tert-Butyl 3-(6-Hydroxy-2-Methylpyrimidin-4-Yl)Piperidine-1-Carboxylate
CAS No.	1260178-75-3
Molecular Formula	C15H23N3O3
Molecular Weight	293.36 g/mol
Synonyms	1-Boc-3-(6-hydroxy-2-methylpyrimidin-4-yl)piperidine; tert-Butyl 3-(6-hydroxy-2-methyl-4-pyrimidinyl)-1-piperidinecarboxylate; 3-(6-Hydroxy-2-methylpyrimidin-4-yl)piperidine-1-carboxylic acid tert-butyl ester; 1-Piperidinecarboxylic acid, 3-(6-hydroxy-2-methyl-4-pyrimidinyl)-, 1,1-dimethylethyl ester; Boc-3-(6-hydroxy-2-methylpyrimidin-4-yl)piperidine; 1260178-75-3; 3-(6-Hydroxy-2-methylpyrimidin-4-yl)-1-Boc-piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(6-Hydroxy-2-Methylpyrimidin-4-Yl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles suitable for pharmaceutical intermediate applications, ensuring reliable supply for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.