Description

2-Chloromethyl-6-Hydroxy-1H-Quinazolin-4-One is a high-purity, functionalized quinazolinone derivative that serves as a critical synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for targeted synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential kinase inhibitors, anticancer agents, and other biologically active quinazoline-based compounds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new therapeutic candidates.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel herbicides, fungicides, or plant growth regulators.
• Chemical Synthesis: The reactive chloromethyl group allows for further functionalization, making it valuable for creating custom ligands, catalysts, or specialty polymers.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for fundamental organic chemistry research and custom synthesis projects.

Basic Information

Product Name	2-Chloromethyl-6-Hydroxy-1H-Quinazolin-4-One
CAS No.	1258977-05-7
Molecular Formula	C9H7ClN2O2
Molecular Weight	210.62 g/mol
Synonyms	6-Hydroxy-2-(chloromethyl)quinazolin-4(1H)-one; 2-(Chloromethyl)-6-hydroxy-1,4-dihydroquinazolin-4-one; 2-(Chloromethyl)-6-hydroxy-4(1H)-quinazolinone; 4(1H)-Quinazolinone, 2-(chloromethyl)-6-hydroxy-; 1258977-05-7; 2-Chloromethyl-6-hydroxyquinazolin-4(1H)-one
EINECS	Contact for details

Quality Control

Our 2-Chloromethyl-6-Hydroxy-1H-Quinazolin-4-One is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound may be light-sensitive and hygroscopic; handle and store under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.