Description

5-Chloro-2-Chloromethyl-1H-Quinazolin-4-One is a high-purity, functionalized quinazolinone derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its bifunctional reactivity, offering distinct sites for nucleophilic substitution and further molecular elaboration, which is essential for constructing complex heterocyclic scaffolds. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly those targeting kinase inhibition or other biological pathways where the quinazolinone core is pharmacologically active.
• Agrochemical Research: Used in developing novel herbicides, fungicides, or insecticides, leveraging the bioactive quinazolinone structure.
• Chemical Synthesis: Serves as a versatile precursor for creating more complex heterocyclic compounds through reactions at the chloromethyl and chloro substituents.
• Material Science: Potential intermediate in the development of organic electronic materials or specialty polymers with unique properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the discovery of new chemical entities.

Basic Information

Product Name	5-Chloro-2-Chloromethyl-1H-Quinazolin-4-One
CAS No.	1258977-03-5
Molecular Formula	C9H6Cl2N2O
Molecular Weight	229.06 g/mol
Synonyms	5-Chloro-2-(chloromethyl)-4(1H)-quinazolinone; 2-Chloromethyl-5-chloro-1H-quinazolin-4-one; 4(1H)-Quinazolinone, 5-chloro-2-(chloromethyl)-; 5-Chloro-2-chloromethylquinazolin-4(1H)-one
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Chloromethyl-1H-Quinazolin-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. Due to its light-sensitive nature, prolonged exposure to direct light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.