Description

Fmoc-6-Fluoro-D-Tryptophan CAS NO 1257853-57-8 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the unique physicochemical properties of a fluorinated tryptophan residue into peptide sequences, enhancing stability and enabling structure-activity relationship (SAR) studies. It is an essential building block for pharmaceutical researchers and peptide manufacturers developing novel therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptides.
• Pharmaceutical Research & Development: Used to synthesize peptide-based drug candidates, including GPCR ligands, enzyme inhibitors, and antimicrobial peptides, where fluorination modulates bioavailability and metabolic stability.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescent or radiolabeled peptides for imaging, diagnostics, and target engagement studies.
• Structural Biology Studies: Incorporation into peptides and proteins for Nuclear Magnetic Resonance (NMR) and X-ray crystallography to investigate folding, dynamics, and protein-ligand interactions.
• Chemical Biology Tool Development: Essential for creating peptide libraries and site-specifically modified biomolecules to study biological pathways and protein function.

Basic Information

Product Name	Fmoc-6-Fluoro-D-Tryptophan
CAS No.	1257853-57-8
Molecular Formula	C₂₆H₂₁FN₂O₄
Molecular Weight	444.46 g/mol
Synonyms	Fmoc-6-F-D-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-fluoro-D-tryptophan; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(6-fluoro-1H-indol-3-yl)propanoic acid; Fmoc-6-Fluoro-D-Trp; 6-Fluoro-D-tryptophan Fmoc derivative; N-α-Fmoc-6-fluoro-D-tryptophan; Fmoc-6-F-D-Tryptophan; Fmoc-D-6-F-Trp
EINECS	Contact for details

Quality Control

Our Fmoc-6-Fluoro-D-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via MS and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.