Description

Fmoc-5-Fluoro-D-Tryptophan CAS NO 1257852-79-1 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound is critical for introducing the unique structural and electronic properties of a fluorinated D-tryptophan residue into peptide chains, enabling the development of novel bioactive molecules with enhanced stability, binding affinity, and metabolic resistance. It is an essential building block for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on developing next-generation peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, used to incorporate 5-fluoro-D-tryptophan into complex peptide sequences.
• Pharmaceutical Research & Development: Serves as a critical intermediate in the discovery and development of novel peptide drugs, including GPCR-targeted therapies, enzyme inhibitors, and antimicrobial peptides.
• Chemical Biology & Probe Development: Used to create fluorinated peptide probes for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways via 19F NMR spectroscopy.
• Peptidomimetics & Conformation Studies: The fluorine atom and D-configuration allow for fine-tuning of peptide backbone conformation, lipophilicity, and electronic properties in the design of peptidomimetics.
• Radiopharmaceutical Precursors: Can serve as a precursor for the synthesis of fluorinated peptides intended for Positron Emission Tomography (PET) imaging, leveraging the fluorine atom for radiolabeling (18F).
• Academic & Institutional Research: A valuable reagent for universities and research institutes conducting fundamental studies in organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Item	Details
Product Name	Fmoc-5-Fluoro-D-Tryptophan
CAS No.	1257852-79-1
Molecular Formula	C26H21FN2O4
Molecular Weight	444.46 g/mol
Synonyms	Fmoc-5-F-D-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-fluoro-D-tryptophan; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-fluoro-1H-indol-3-yl)propanoic acid; 5-Fluoro-D-tryptophan Fmoc derivative; Fmoc-5-F-Trp(D)-OH; Nα-Fmoc-5-fluoro-D-tryptophan; Fmoc-D-5-F-Trp; N-Fmoc-5-fluoro-D-tryptophan
EINECS	Contact for details

Quality Control

Our Fmoc-5-Fluoro-D-Tryptophan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.