Description

Fmoc-5-Chloro-L-Tryptophan CAS NO 1257849-07-2 is a protected derivative of the essential amino acid tryptophan, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring the precise incorporation of a halogenated tryptophan residue into peptide chains, enabling advanced studies in protein structure-activity relationships. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptides.
• Pharmaceutical Research: Used to synthesize peptide-based drug candidates, especially those targeting neurological disorders, cancer, and metabolic diseases where modified tryptophan residues can enhance binding affinity or stability.
• Bioconjugation & Probe Development: The chloro-substituent provides a handle for further chemical modification (e.g., cross-coupling reactions), facilitating the creation of fluorescent labels, affinity tags, or peptide-drug conjugates.
• Academic & Institutional R&D: Employed in university and government laboratories for fundamental research in biochemistry, medicinal chemistry, and chemical biology.
• Production of Reference Standards: Serves as a high-purity intermediate for the preparation of certified reference materials and analytical standards used in quality control.

Basic Information

Product Name	Fmoc-5-Chloro-L-Tryptophan
CAS No.	1257849-07-2
Molecular Formula	C₂₆H₂₁ClN₂O₄
Molecular Weight	460.91 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-chloro-L-tryptophan; Fmoc-5-Cl-Trp-OH; 5-Chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tryptophan; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(5-chloro-1H-indol-3-yl)propanoic acid; Fmoc-5-chlorotryptophan; N-Fmoc-5-chloro-L-tryptophan; Fmoc-L-5-chlorotryptophan; 5-Chloro-L-tryptophan, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-5-Chloro-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). We provide a Certificate of Analysis (COA) with each shipment, detailing all critical specifications to ensure it meets the stringent requirements for advanced peptide synthesis and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.