Description

2-Amino-5-Bromo-3-(Trifluoromethoxy)Nitrobenzene, also known as 2-Amino-5-Bromo-3-Nitro-Alpha,Alpha,α-Trifluoroanisole, is a specialized aromatic intermediate distinguished by its unique trifluoromethoxy and nitro functional groups. This compound is valued for its role as a critical building block in the synthesis of advanced molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research and development chemists and process engineers working on novel active ingredients, where its specific substitution pattern enables precise molecular modifications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, or infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity imparted by the halogen and trifluoromethoxy groups.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers, liquid crystals, or organic electronic materials.
• Dye and Pigment Chemistry: Acts as an intermediate for creating complex, high-performance dyes and organic pigments.
• Cross-Coupling Reactions: The bromo and amino groups make it a versatile substrate for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, or Ullmann couplings.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes, enzyme inhibitors, or affinity tags for biochemical research.

Basic Information

Product Name	2-Amino-5-Bromo-3-(Trifluoromethoxy)Nitrobenzene
CAS No.	1257535-31-1
Molecular Formula	C7H4BrF3N2O3
Molecular Weight	301.02 g/mol
Synonyms	2-Amino-5-Bromo-3-Nitro-Alpha,Alpha,α-Trifluoroanisole; 5-Bromo-2-nitro-3-(trifluoromethoxy)aniline; 1-Amino-4-bromo-2-nitro-5-(trifluoromethoxy)benzene; 2-Nitro-5-bromo-3-(trifluoromethoxy)aniline; 3-(Trifluoromethoxy)-5-bromo-2-nitroaniline; Benzenamine, 5-bromo-2-nitro-3-(trifluoromethoxy)-; 5-Bromo-3-nitro-2-(trifluoromethoxy)aniline
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Bromo-3-(Trifluoromethoxy)Nitrobenzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed and under an inert atmosphere if necessary to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.