Description

2-Bromo-5-Chloro-4-(Trifluoromethyl)Pyrimidine is a high-value halogenated pyrimidine building block, essential for advanced organic synthesis and pharmaceutical research. Its unique structure, featuring bromine, chlorine, and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronics, such as OLEDs and semiconductors.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes and enzyme inhibitors for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for custom synthesis projects requiring high-purity, specialized heterocycles.

Basic Information

Product Name	2-Bromo-5-Chloro-4-(Trifluoromethyl)Pyrimidine
CAS No.	1257535-09-3
Molecular Formula	C5HBrClF3N2
Molecular Weight	255.42 g/mol
Synonyms	5-Chloro-2-bromo-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)-2-bromo-5-chloropyrimidine; 2-Bromo-5-chloro-4-trifluoromethylpyrimidine; Pyrimidine, 2-bromo-5-chloro-4-(trifluoromethyl)-; 1257535-09-3; BCTP; Bromochloro(trifluoromethyl)pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Chloro-4-(Trifluoromethyl)Pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.