Description

5-(Difluoromethoxy)-2-Methoxyaniline is a specialized aromatic amine derivative featuring both difluoromethoxy and methoxy substituents, making it a valuable building block in advanced organic synthesis. Its unique structure provides a versatile platform for creating complex molecules with tailored properties. This high-purity intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing high-performance, light-fast dyes and functional pigments.
• Liquid Crystal & OLED Development: Employed in the synthesis of fluorinated components for display and lighting technologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring this precise chemical scaffold.

Basic Information

Product Name	5-(Difluoromethoxy)-2-Methoxyaniline
CAS No.	1256627-90-3
Molecular Formula	C8H9F2NO2
Molecular Weight	189.16 g/mol
Synonyms	2-Methoxy-5-(difluoromethoxy)aniline; 5-(Difluoromethoxy)-2-methoxybenzenamine; 2-Amino-4-(difluoromethoxy)anisole; Benzenamine, 2-methoxy-5-(difluoromethoxy)-; 2-Methoxy-5-difluoromethoxyaniline; 5-Difluoromethoxy-2-methoxyaniline; 2-Methoxy-5-(difluoromethoxy)phenylamine
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethoxy)-2-Methoxyaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.