Description

5-Pyrimidinecarboxamide, 2-[(1A,5A,6A)-6-[[(6-Fluoro-2-Quinolinyl)Methyl]Amino]-3-Azabicyclo[3.1.0]Hex-3-Yl]-n-Hydroxy- is a sophisticated, high-purity chemical intermediate featuring a unique bicyclic scaffold fused with pyrimidine and quinoline pharmacophores. This compound is of significant value for pharmaceutical research and development, particularly in the discovery of novel enzyme inhibitors. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting specific enzymes or receptors.
• HDAC Inhibitor Research: Serves as a core structural component in the research and development of histone deacetylase (HDAC) inhibitors, a promising class of oncology therapeutics.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes for preclinical and clinical trial material production.
• Biochemical Probe Synthesis: Utilized to create chemical tools for studying epigenetic mechanisms and cellular pathways in biological research.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring advanced, multi-cyclic heteroaromatic frameworks.

Basic Information

Product Name	5-Pyrimidinecarboxamide, 2-[(1A,5A,6A)-6-[[(6-Fluoro-2-Quinolinyl)Methyl]Amino]-3-Azabicyclo[3.1.0]Hex-3-Yl]-n-Hydroxy-
CAS No.	1256448-47-1
Molecular Formula	C20H20FN5O2
Molecular Weight	381.41 g/mol
Synonyms	2-[(1A,5A,6A)-6-[[(6-Fluoro-2-Quinolinyl)Methyl]Amino]-3-Azabicyclo[3.1.0]Hex-3-Yl]-N-Hydroxy-5-Pyrimidinecarboxamide; N-Hydroxy-2-((1R,5S,6S)-6-(((6-fluoro-2-quinolinyl)methyl)amino)-3-azabicyclo[3.1.0]hex-3-yl)-5-pyrimidinecarboxamide; (1R,5S,6S)-N6-((6-Fluoro-2-quinolinyl)methyl)-3-(2-(hydroxycarbamoyl)pyrimidin-5-yl)-3-azabicyclo[3.1.0]hexan-6-amine; HDAC Inhibitor Intermediate; Bicyclic Hydroxamic Acid Derivative; Azabicyclohexane Pyrimidinecarboxamide
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for advanced research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. Our quality system is designed to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.