Description

1-(4-Bromophenyl)-2,2-Difluoroethan-1-Ol is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those incorporating difluoroethyl motifs for improved metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the bromophenyl and difluoroethanol groups confer specific biological activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science: Potential monomer or additive in the synthesis of specialty polymers and liquid crystals.
• Fluorine Chemistry Library Building: Essential for constructing diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck).

Basic Information

Item	Details
Product Name	1-(4-Bromophenyl)-2,2-Difluoroethan-1-Ol
CAS No.	1255706-18-3
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	4-Bromo-α,α-difluorobenzeneethanol; 1-(4-Bromophenyl)-2,2-difluoroethanol; 2,2-Difluoro-1-(4-bromophenyl)ethanol; (4-Bromophenyl)difluoromethyl carbinol; α,α-Difluoro-4-bromobenzeneethanol; p-Bromo-α,α-difluorophenethyl alcohol
EINECS	Contact for details

Quality Control

Our 1-(4-Bromophenyl)-2,2-Difluoroethan-1-Ol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.