Description

n-(2,4-Difluoro-3-Formylphenyl)Propane-1-Sulfonamide is a high-purity, advanced pharmaceutical intermediate characterized by its distinct difluoro-substituted aromatic aldehyde and sulfonamide functional groups. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. Pharmaceutical R&D teams and fine chemical manufacturers need this material for developing next-generation drug candidates, leveraging its unique structure to impart specific biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Protease Inhibitor Precursor: Used in the research and development of enzyme inhibitors, where the sulfonamide moiety acts as a key pharmacophore.
• Agrochemical Synthesis: Serves as an intermediate in creating advanced herbicides and fungicides, utilizing the fluorine atoms for enhanced bioactivity and environmental persistence.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials due to its conjugated aldehyde system.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying protein-ligand interactions and cellular processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity fluorinated intermediates.

Basic Information

Product Name	n-(2,4-Difluoro-3-Formylphenyl)Propane-1-Sulfonamide
CAS No.	1254567-71-9
Molecular Formula	C10H11F2NO3S
Molecular Weight	263.26 g/mol
Synonyms	1-Propanesulfonamide, N-(2,4-difluoro-3-formylphenyl)-; 3-[(Propylsulfonyl)amino]-2,4-difluorobenzaldehyde; N-(3-Formyl-2,4-difluorophenyl)propane-1-sulfonamide; 2,4-Difluoro-3-[(propylsulfonyl)amino]benzaldehyde; DFPA Sulfonamide; 1254567-71-9; Benzaldehyde, 2,4-difluoro-3-[(propylsulfonyl)amino]-
EINECS	Contact for details

Quality Control

Our n-(2,4-Difluoro-3-Formylphenyl)Propane-1-Sulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.