Description

1-(6-Chloro-5-Methylpyrimidin-4-Yl)-2,3-Dihydro-1H-Pyrrolo[3,2-B]Pyridine is a high-purity, advanced pharmaceutical intermediate with a complex fused heterocyclic structure. Its core value lies in its role as a critical building block for the synthesis of novel, targeted therapeutic agents, particularly in oncology and other disease areas. This compound is essential for research institutions and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for targeted cancer therapies.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and optimizing potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities for various disease targets.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of candidate drugs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and development services.
• Bioconjugation & Probe Synthesis: Potential use in creating chemical probes for biochemical and cellular assays.

Basic Information

Product Name	1-(6-Chloro-5-Methylpyrimidin-4-Yl)-2,3-Dihydro-1H-Pyrrolo[3,2-B]Pyridine
CAS No.	1254360-69-4
Molecular Formula	C12H11ClN4
Molecular Weight	246.70 g/mol
Synonyms	1-(6-Chloro-5-methylpyrimidin-4-yl)-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine; 1H-Pyrrolo[3,2-b]pyridine, 1-(6-chloro-5-methyl-4-pyrimidinyl)-2,3-dihydro-; 6-Chloro-5-methyl-4-(2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)pyrimidine; CAS 1254360-69-4
EINECS	Contact for details

Quality Control

Our 1-(6-Chloro-5-Methylpyrimidin-4-Yl)-2,3-Dihydro-1H-Pyrrolo[3,2-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.