Description

Ethyl 5-Hydroxy-2-(Methylthio)-7-Oxo-8-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in early-stage drug discovery.
• Chemical Synthesis: Acts as a versatile scaffold for constructing complex polyheterocyclic systems due to its reactive functional groups.
• Academic Research: Employed in universities and research institutes for studying heterocyclic chemistry and developing new synthetic methodologies.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for cGMP production of clinical trial materials.

Basic Information

Product Name	Ethyl 5-Hydroxy-2-(Methylthio)-7-Oxo-8-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	1253791-97-7
Molecular Formula	C18H15N3O4S
Molecular Weight	369.40 g/mol
Synonyms	Ethyl 5-hydroxy-2-(methylthio)-7-oxo-8-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate; 8-Phenyl-5-hydroxy-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; 1253791-97-7; Pyrido[2,3-d]pyrimidine-6-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our Ethyl 5-Hydroxy-2-(Methylthio)-7-Oxo-8-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent specifications required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.