Description

(4S)-4-(Boc-Amino)-1-Fmoc-D-Proline CAS NO 1253791-18-2 is a high-purity, dual-protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control and orthogonal protecting group strategies in complex molecule assembly. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers specializing in the development of peptide-based therapeutics, diagnostics, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of D-proline derivatives into peptide chains, enabling the creation of structurally diverse and stable peptide sequences.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of peptide drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutic agents.
• Combinatorial Chemistry Libraries: Used to generate libraries of novel compounds for high-throughput screening in drug discovery programs.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling and modification of peptides for diagnostic imaging and biochemical research tools.
• Academic and Industrial Research: Essential for methodological studies in organic synthesis and peptide science, exploring new synthetic routes and protecting group methodologies.

Basic Information

Product Name	(4S)-4-(Boc-Amino)-1-Fmoc-D-Proline
CAS No.	1253791-18-2
Molecular Formula	C26H30N2O6
Molecular Weight	466.53 g/mol
Synonyms	1-Fmoc-4-[(tert-butoxycarbonyl)amino]-D-proline; Fmoc-D-Pro(4-N-Boc)-OH; (4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-pyrrolidinecarboxylic acid; Boc-NH-D-Pro(4)-OH-Fmoc; 4-[(tert-Butoxycarbonyl)amino]-1-(9-fluorenylmethoxycarbonyl)-D-proline; D-Proline, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-4-(Boc-amino)-D-proline
EINECS	Contact for details

Quality Control

Every batch of (4S)-4-(Boc-Amino)-1-Fmoc-D-Proline is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and consistent performance. Our standard quality control includes identity confirmation by spectroscopic methods (NMR, IR) and purity assessment by HPLC. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.