Description

Ethyl 5-Hydroxy-7-Oxo-2-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in oncology and other disease areas targeting specific enzymatic pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Biochemical Reagent: Acts as a reference standard or a substrate analog in enzymatic assays to study biological pathways and mechanisms of action.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional laboratories for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	Ethyl 5-Hydroxy-7-Oxo-2-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	1253791-09-1
Molecular Formula	C₁₇H₁₃N₃O₄
Molecular Weight	323.30 g/mol
Synonyms	Ethyl 5-hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate; 5-Hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; 1253791-09-1; Ethyl 2-phenyl-5,7-dihydroxy-8-azapurine-6-carboxylate (tautomeric form); Pyrido[2,3-d]pyrimidine-6-carboxylic acid derivative; 7,8-Dihydropyrido[2,3-d]pyrimidine intermediate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Hydroxy-7-Oxo-2-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) documenting full specifications are provided with every shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.